The Division's research in statistical genetics is led by Professor Wang. His recent work includes various genetic data analyses, linkage and association mapping of disease genes, modeling and methodology development for association mapping of quantitative trait loci, and haplotype association analysis of single nucleotide polymorphisms (SNPs).

Specifically, in work with Professor Zeng ofNorth Carolina State University, Dr. Wang explored the definitions and properties of additive, dominance and epistatic effects of QTL and partition of genetic variance in an equilibrium as well as in a disequilibrium population.  In joint work with Professors Weir and Zeng he developed a population-based multipoint LD method for fine mapping of quantitative trait loci. A mixture model was applied to describe the relationship between phenotype and QTL genotypes. An EM algorithm was developed to estimate the genetic effects of QTL and joint haplotype frequencies of QTL and markers.

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